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Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott, Mark; Favre-Guilmard, Christine; Liu, Sai Man; Maignel, Jacquie; Masuyer, Geoffrey; Beard, Matthew; Boone, Christopher; Carré, Denis; Kalinichev, Mikhail; Lezmi, Stephane; Mir, Imran; Nicoleau, Camille; Palan, Shilpa; Perier, Cindy; Raban, Elsa; Zhang, Sicai; Dong, Min; Stenmark, Pål; Krupp, Johannes.
Afiliación
  • Elliott M; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  • Favre-Guilmard C; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Liu SM; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  • Maignel J; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-106 91, Sweden.
  • Beard M; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  • Boone C; Department of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  • Carré D; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Kalinichev M; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Lezmi S; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Mir I; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  • Nicoleau C; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Palan S; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  • Perier C; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Raban E; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  • Zhang S; Department of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  • Dong M; Department of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  • Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-106 91, Sweden.
  • Krupp J; Department of Experimental Medical Science, Lund University, 221 00 Lund, Sweden.
Sci Adv ; 5(1): eaau7196, 2019 01.
Article en En | MEDLINE | ID: mdl-30746458
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Recombinantes / Toxinas Botulínicas Tipo A / Sinaptotagmina II Idioma: En Revista: Sci Adv Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Recombinantes / Toxinas Botulínicas Tipo A / Sinaptotagmina II Idioma: En Revista: Sci Adv Año: 2019 Tipo del documento: Article