Striatal spreading depolarization: Possible implication in levodopa-induced dyskinetic-like behavior.
Mov Disord
; 34(6): 832-844, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30759320
ABSTRACT
OBJECTIVE:
Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated.METHODS:
We characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses.RESULTS:
We found that striatal spreading depolarization requires the concomitant activation of D1-like DA and N-methyl-d-aspartate receptors, and it is reduced in experimental PD. Chronic l-dopa treatment, inducing dyskinesia in the parkinsonian condition, increases the occurrence and speed of propagation of striatal spreading depolarization, which has a direct impact on one of the signaling pathways downstream from the activation of D1 receptors.CONCLUSION:
Striatal spreading depolarization might contribute to abnormal basal ganglia activity in the dyskinetic condition and represents a possible therapeutic target. © 2019 International Parkinson and Movement Disorder Society.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Levodopa
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Transmisión Sináptica
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Cuerpo Estriado
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Trastornos Parkinsonianos
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Discinesia Inducida por Medicamentos
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Neuronas Dopaminérgicas
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Neuronas
Idioma:
En
Revista:
Mov Disord
Asunto de la revista:
NEUROLOGIA
Año:
2019
Tipo del documento:
Article