Exenatide once-weekly improves metabolic parameters, endothelial dysfunction and carotid intima-media thickness in patients with type-2 diabetes: An 8-month prospective study.
Diabetes Res Clin Pract
; 149: 163-169, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30759365
ABSTRACT
AIM:
To evaluate the effect of exenatide long acting release (LAR) on carotid intima-media thickness (IMT) and endothelial function in patients with type 2 diabetes mellitus.METHODS:
Sixty subjects with type 2 diabetes mellitus were treated with exenatide LAR as add-on to stable doses of metformin for 8â¯months in an open label study. Anthropometric variables, lipid profile and glycemic parameters were assessed by routine analysis. Carotid IMT by Doppler ultrasound and endothelial function by flow-mediated dilation of the brachial artery were also assessed.RESULTS:
Exenatide significantly improved fasting glycaemia (from 8.8⯱â¯2.8 to 7.3⯱â¯2.2â¯mmol/L, pâ¯<â¯0.0001), HbA1c (from 8.0⯱â¯0.4 to 6.9⯱â¯1.1%, pâ¯<â¯0.0001), body mass index (from 33⯱â¯9 to 31⯱â¯6â¯kg/m2, pâ¯=â¯0.0348) and waist circumference (from 109⯱â¯13 to 106⯱â¯13â¯cm, pâ¯=â¯0.0105). There was a significant improvement of the lipid profile, except in triglyceride level where no changes were observed. Carotid IMT and flow-mediated dilation were also improved (from 0.98⯱â¯0.14 to 0.87⯱â¯0.15â¯mm and from 5.8⯱â¯1.3 to 6.8⯱â¯1.7%, respectively; pâ¯<â¯0.0001 for both).CONCLUSIONS:
Treatment with exenatide LAR led to improved cardio-metabolic parameters, including carotid IMT and flow-mediated dilation, independently of glucometabolic control. These results may help to explain, at least in part, the cardiovascular safety of exenatide LAR, as recently reported in cardiovascular outcome trials.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
/
Aterosclerosis
/
Exenatida
/
Hipoglucemiantes
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Diabetes Res Clin Pract
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2019
Tipo del documento:
Article