NH2OH-HCl-Mediated Umpolung α-Methylsulfonylation of α-Sulfonyl Ketones with Methylsulfoxides: Synthesis of α,ß-Bis-sulfonyl Arylketones.
Org Lett
; 21(6): 1832-1836, 2019 03 15.
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| ID: mdl-30788972
ABSTRACT
In this paper, a novel and efficient route for the synthesis of α,ß-bis-sulfonyl arylketones via an NH2OH-HCl-mediated intermolecular umpolung α-methylsulfonylation of α-sulfonyl ketones with methylsulfoxides is described. A plausible mechanism is proposed and discussed. Various reaction conditions for this efficient, one-pot, environmentally friendly transformation were investigated.
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MEDLINE
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En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2019
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Article