Structural and functional characterization of the membrane-permeabilizing activity of <i>Nicotiana occidentalis</i> defensin NoD173 and protein engineering to enhance oncolysis.

Lay, Fung T; Ryan, Gemma F; Caria, Sofia; Phan, Thanh Kha; Veneer, Prem K; White, Julie A; Kvansakul, Marc; Hulett, Mark D

Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis.

Lay, Fung T; Ryan, Gemma F; Caria, Sofia; Phan, Thanh Kha; Veneer, Prem K; White, Julie A; Kvansakul, Marc; Hulett, Mark D.

Afiliación

Lay FT; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Ryan GF; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Caria S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Phan TK; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Veneer PK; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
White JA; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Kvansakul M; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Hulett MD; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.

FASEB J ; 33(5): 6470-6482, 2019 05.

Article en En | MEDLINE | ID: mdl-30794440

Asunto(s)

Sustitución de Aminoácidos; Antineoplásicos Fitogénicos; Defensinas; Neoplasias; Nicotiana; Proteínas de Plantas; Antineoplásicos Fitogénicos/química; Antineoplásicos Fitogénicos/farmacología; Permeabilidad de la Membrana Celular/efectos de los fármacos; Defensinas/química; Defensinas/genética; Defensinas/farmacología; Células HeLa; Células Endoteliales de la Vena Umbilical Humana; Humanos; Mutación Missense; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Neoplasias/patología; Células PC-3; Proteínas de Plantas/química; Proteínas de Plantas/genética; Proteínas de Plantas/farmacología; Multimerización de Proteína; Estructura Cuaternaria de Proteína; Relación Estructura-Actividad; Nicotiana/química; Nicotiana/genética; Células U937

Palabras clave

X-ray crystallography; anticancer; antimicrobial peptide; cell permeabilization; innate immunity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas de Plantas / Nicotiana / Sustitución de Aminoácidos / Defensinas / Neoplasias / Antineoplásicos Fitogénicos Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article

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