Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling.

Naritomi, Yoichi; Sanoh, Seigo; Ohta, Shigeru

Naritomi, Yoichi; Sanoh, Seigo; Ohta, Shigeru.

Afiliación

Naritomi Y; Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc.
Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University.
Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University.

Biol Pharm Bull ; 42(3): 327-336, 2019.

Article en En | MEDLINE | ID: mdl-30828063

Asunto(s)

Descubrimiento de Drogas/métodos; Hígado/metabolismo; Animales; Humanos; Ratones; Ratones Transgénicos; Microsomas Hepáticos; Preparaciones Farmacéuticas/sangre; Farmacocinética

Palabras clave

allometric scaling; humanized mouse; in vitroin vivo extrapolation; pharmacokinetics; prediction

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Descubrimiento de Drogas / Hígado Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2019 Tipo del documento: Article

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