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Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
Alcock, Lisa J; Oliveira, Bruno L; Deery, Michael J; Pukala, Tara L; Perkins, Michael V; Bernardes, Gonçalo J L; Chalker, Justin M.
Afiliación
  • Alcock LJ; Flinders University , College of Science and Engineering , Sturt Road , Bedford Park , South Australia 5042 , Australia.
  • Oliveira BL; Flinders University , Institute for NanoScale Science and Technology , Sturt Road , Bedford Park , South Australia 5042 , Australia.
  • Deery MJ; Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
  • Pukala TL; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1QW , United Kingdom.
  • Perkins MV; The University of Adelaide , School of Physical Sciences , Adelaide , South Australia 5005 , Australia.
  • Bernardes GJL; Flinders University , College of Science and Engineering , Sturt Road , Bedford Park , South Australia 5042 , Australia.
  • Chalker JM; Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
ACS Chem Biol ; 14(4): 594-598, 2019 04 19.
Article en En | MEDLINE | ID: mdl-30893551
ABSTRACT
Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácidos Sulfénicos / Sondas Moleculares / Cisteína / Norbornanos Tipo de estudio: Diagnostic_studies Idioma: En Revista: ACS Chem Biol Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácidos Sulfénicos / Sondas Moleculares / Cisteína / Norbornanos Tipo de estudio: Diagnostic_studies Idioma: En Revista: ACS Chem Biol Año: 2019 Tipo del documento: Article