The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease.
Biochem J
; 476(6): 931-950, 2019 03 22.
Article
en En
| MEDLINE
| ID: mdl-30902898
ABSTRACT
The discoidin, CUB, and LCCL domain-containing (DCBLD) receptor family are composed of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1). These proteins are highly conserved across vertebrates and possess similar domain structure to that of neuropilins, which act as critical co-receptors in developmental processes. Although DCBLD1 remains largely uncharacterized, the functional and mechanistic roles of DCBLD2 are emerging. This review provides a comprehensive discussion of this presumed receptor family, ranging from structural and signaling aspects to their associations with cancer, physiology, and development.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas de la Membrana
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Proteínas de Neoplasias
/
Neoplasias
Idioma:
En
Revista:
Biochem J
Año:
2019
Tipo del documento:
Article