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Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wan, Jinqiao; Wu, Xiangyang; Deval, Jerome; Fung, Amy; Jin, Zhinan; Tan, Hua; Shaw, Kenneth; Kang, Hyunsoon; Zhang, Qingling; Tam, Yuen; Stoycheva, Antitsa; Jekle, Andreas; Smith, David B; Beigelman, Leonid.
Afiliación
  • Wang G; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Dyatkina N; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Prhavc M; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Williams C; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Serebryany V; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Hu Y; Department of Medicinal Chemistry , WuXi AppTec , Shanghai 200131 , P. R. China.
  • Huang Y; Department of Medicinal Chemistry , WuXi AppTec , Shanghai 200131 , P. R. China.
  • Wan J; Department of Medicinal Chemistry , WuXi AppTec , Shanghai 200131 , P. R. China.
  • Wu X; Department of Medicinal Chemistry , WuXi AppTec , Shanghai 200131 , P. R. China.
  • Deval J; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Fung A; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Jin Z; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Tan H; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Shaw K; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Kang H; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Zhang Q; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Tam Y; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Stoycheva A; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Jekle A; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Smith DB; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
  • Beigelman L; Janssen BioPharma, Inc. , South San Francisco , California 94080 , United States.
J Med Chem ; 62(9): 4555-4570, 2019 05 09.
Article en En | MEDLINE | ID: mdl-30951311
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Nucleótidos de Uracilo / Uridina / Profármacos / Hepacivirus / Alanina Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Nucleótidos de Uracilo / Uridina / Profármacos / Hepacivirus / Alanina Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article