Compare Fuhrman Nuclear and Chromophobe Tumor Grade on Chromophobe RCC.
Open Med (Wars)
; 14: 336-342, 2019.
Article
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| MEDLINE
| ID: mdl-31032425
ABSTRACT
BACKGROUND:
Chromophobe renal cell carcinoma (chRCC) has a favorable prognosis. Due to irregular nuclei and nuclear pleomorphism, chRCC has a high Fuhrman nuclear grade (FNG). The chromophobe tumor grade (CTG) is a novel three-tier grading system that has been reported to be a better prognosticator than the traditional FNG. We compared the two nuclear grading systems in terms of patients' clinical outcomes. PATIENTS ANDMETHOD:
We performed this retrospective chart review of all patients with chRCC from 2000 to 2017. All pathologic features and CTG and FNG results were re-evaluated.RESULT:
Eighteen patients' records were reviewed with a mean follow-up of 70.6 months. The nuclear grading distribution was as follows FNG 2, 56%; FNG 3, 39%; FNG 4, 5%; CTG 1, 78%; CTG 2, 17%; and CTG 3, 6%. Only one patient died. This patient had adrenal invasion, lung metastasis, sarcomatoid change and tumor necrosis, and the tumor was graded as FNG 4 and CTG 3. Overall survival was associated with both FNG and CTG.CONCLUSION:
Chromophobe RCC was associated with a low rate of cancer-specific death and sarcomatoid differentiation. Both FNG and CTG were associated with overall survival.
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MEDLINE
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En
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Open Med (Wars)
Año:
2019
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Article