Marine-Steroid Derivative 5&#945;-Androst-3ß, 5&#945;, 6ß-triol Protects Retinal Ganglion Cells from Ischemiaâ»Reperfusion Injury by Activating Nrf2 Pathway.

Sheng, Longxiang; Lu, Bingzheng; Chen, Hui; Du, Yun; Chen, Chen; Cai, Wei; Yang, Yang; Tian, Xuyan; Huang, Zhaofeng; Chi, Wei; Lin, Suizhen; Yan, Guangmei; Yin, Wei

Marine-Steroid Derivative 5α-Androst-3ß, 5α, 6ß-triol Protects Retinal Ganglion Cells from Ischemiaâ»Reperfusion Injury by Activating Nrf2 Pathway.

Sheng, Longxiang; Lu, Bingzheng; Chen, Hui; Du, Yun; Chen, Chen; Cai, Wei; Yang, Yang; Tian, Xuyan; Huang, Zhaofeng; Chi, Wei; Lin, Suizhen; Yan, Guangmei; Yin, Wei.

Afiliación

Sheng L; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. shenglx@mail2.sysu.edu.cn.
Lu B; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. lubzh3@mail2.sysu.edu.cn.
Chen H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. 129huihui@163.com.
Du Y; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. duyun3@mail2.sysu.edu.cn.
Chen C; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. chench376@mail2.sysu.edu.cn.
Cai W; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. caiw28@mail2.sysu.edu.cn.
Yang Y; Guangzhou Cellprotek Pharmaceutical, G Building F/4, 3 Lanyue Road, Science City, Guangzhou 510663, China. yangyang@cellprotek.com.
Tian X; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. tianxy25@mail2.sysu.edu.cn.
Huang Z; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. hzhaof@mail.sysu.edu.cn.
Chi W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. chiwei@mail.sysu.edu.cn.
Lin S; Guangzhou Cellprotek Pharmaceutical, G Building F/4, 3 Lanyue Road, Science City, Guangzhou 510663, China. linsuizhen@cellprotek.com.
Yan G; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. ygm@mail.sysu.edu.cn.
Yin W; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. yinwei@mail.sysu.edu.cn.

Mar Drugs ; 17(5)2019 May 05.

Article en En | MEDLINE | ID: mdl-31060323

Asunto(s)

Androstanoles/farmacología; Factor 2 Relacionado con NF-E2/deficiencia; Fármacos Neuroprotectores/farmacología; Daño por Reperfusión/tratamiento farmacológico; Células Ganglionares de la Retina/efectos de los fármacos; Esteroides/farmacología; Animales; Técnicas de Cultivo de Célula; Hipoxia de la Célula/efectos de los fármacos; Modelos Animales de Enfermedad; Glaucoma; Hemo-Oxigenasa 1/metabolismo; Inflamación/tratamiento farmacológico; Proteína 1 Asociada A ECH Tipo Kelch/metabolismo; Masculino; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Microglía/efectos de los fármacos; Microglía/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Hipertensión Ocular/tratamiento farmacológico; Estrés Oxidativo/efectos de los fármacos; Ratas; Ratas Sprague-Dawley

Palabras clave

5α-androst-3ß, 5α, 6ß-triol (TRIOL); NF-E2-related factor 2 (Nrf2); acute glaucoma; ischemic-reperfusion (I/R) injury

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Ganglionares de la Retina / Esteroides / Daño por Reperfusión / Fármacos Neuroprotectores / Factor 2 Relacionado con NF-E2 / Androstanoles Tipo de estudio: Prognostic_studies Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2019 Tipo del documento: Article

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