Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio.
Pharmacogenomics
; 20(9): 659-667, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-31068094
ABSTRACT
Aim:
This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials &methods:
13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results &conclusion:
Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Warfarina
/
Prótesis Valvulares Cardíacas
/
Polimorfismo de Nucleótido Simple
/
Factor A de Crecimiento Endotelial Vascular
/
Hemorragia
/
Anticoagulantes
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2019
Tipo del documento:
Article