Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen, Liu Zeng; Yao, Li; Jiao, Ming Ming; Shi, Jing Bo; Tan, Yue; Ruan, Ban Feng; Liu, Xin Hua

Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen, Liu Zeng; Yao, Li; Jiao, Ming Ming; Shi, Jing Bo; Tan, Yue; Ruan, Ban Feng; Liu, Xin Hua.

Afiliación

Chen LZ; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases Anhui Medical University, Hefei, 230032, PR China.
Yao L; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China.
Jiao MM; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases Anhui Medical University, Hefei, 230032, PR China.
Shi JB; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases Anhui Medical University, Hefei, 230032, PR China.
Tan Y; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases Anhui Medical University, Hefei, 230032, PR China.
Ruan BF; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China. Electronic address: bf_ruan@163.com.
Liu XH; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases Anhui Medical University, Hefei, 230032, PR China. Electronic address: xhliuhx@163.com.

Eur J Med Chem ; 175: 114-128, 2019 Aug 01.

Article en En | MEDLINE | ID: mdl-31077997

Asunto(s)

Antiinflamatorios/síntesis química; Antiinflamatorios/farmacología; Flavonoides/síntesis química; Flavonoides/farmacología; Interleucina-6/antagonistas & inhibidores; Óxido Nítrico/antagonistas & inhibidores; Resveratrol/química; Factor de Necrosis Tumoral alfa/antagonistas & inhibidores; Animales; Antiinflamatorios/toxicidad; Flavonoides/química; Flavonoides/toxicidad; Técnicas In Vitro; Concentración 50 Inhibidora; Lipopolisacáridos/toxicidad; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Ratones; Simulación del Acoplamiento Molecular; FN-kappa B/metabolismo; Células RAW 264.7; Relación Estructura-Actividad; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

Anti-inflammatory; Design; Resveratrol-based flavonol; Synthesis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Flavonoides / Interleucina-6 / Factor de Necrosis Tumoral alfa / Resveratrol / Antiinflamatorios / Óxido Nítrico Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article

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