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BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo.
Yang, Wang; Zhang, Guowei; Jiang, Fan; Zeng, Yingfei; Zou, Peng; An, Huihui; Chen, Qing; Ling, Xi; Han, Fei; Liu, Wenbin; Yang, Huan; Liu, Jinyi; Cao, Jia; Ao, Lin.
Afiliación
  • Yang W; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Zhang G; Department of Environmental Health, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Jiang F; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Zeng Y; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Zou P; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • An H; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Chen Q; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Ling X; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Han F; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Liu W; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Yang H; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Liu J; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Cao J; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
  • Ao L; Key Lab for the Medical Protection of Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China. Electronic address: aolin@tmmu.edu.cn.
Toxicol Appl Pharmacol ; 376: 17-37, 2019 08 01.
Article en En | MEDLINE | ID: mdl-31085209
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Espermatozoides / Benzopirenos / Telomerasa / Sirtuina 1 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Mitocondrias Idioma: En Revista: Toxicol Appl Pharmacol Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Espermatozoides / Benzopirenos / Telomerasa / Sirtuina 1 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Mitocondrias Idioma: En Revista: Toxicol Appl Pharmacol Año: 2019 Tipo del documento: Article