Lusianthridin targeting of lung cancer stem cells via Src-STAT3 suppression.

Bhummaphan, Narumol; Petpiroon, Nalinrat; Prakhongcheep, Ornjira; Sritularak, Boonchoo; Chanvorachote, Pithi

Bhummaphan, Narumol; Petpiroon, Nalinrat; Prakhongcheep, Ornjira; Sritularak, Boonchoo; Chanvorachote, Pithi.

Afiliación

Bhummaphan N; Inter-Department Program of Biomedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Petpiroon N; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Prakhongcheep O; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Sritularak B; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Chanvorachote P; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. Electronic

Phytomedicine ; 62: 152932, 2019 Sep.

Article en En | MEDLINE | ID: mdl-31100681

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Neoplasias Pulmonares/tratamiento farmacológico; Células Madre Neoplásicas/efectos de los fármacos; Fenantrenos/farmacología; Factor de Transcripción STAT3/metabolismo; Familia-src Quinasas/metabolismo; Antígeno AC133/metabolismo; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2/metabolismo; Familia de Aldehído Deshidrogenasa 1/metabolismo; Antineoplásicos Fitogénicos/farmacología; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/patología; Línea Celular Tumoral; Cisplatino/farmacología; Dasatinib/farmacología; Regulación hacia Abajo/efectos de los fármacos; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Proteínas de Neoplasias/metabolismo; Células Madre Neoplásicas/metabolismo; Células Madre Neoplásicas/patología; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas c-myc/metabolismo; Retinal-Deshidrogenasa/metabolismo; Factor de Transcripción STAT3/antagonistas & inhibidores; Esferoides Celulares/efectos de los fármacos; Familia-src Quinasas/antagonistas & inhibidores; Familia-src Quinasas/genética

Palabras clave

Cancer stem cells; Lung cancer; Lusianthridin; STAT3; Src; c-Myc

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenantrenos / Células Madre Neoplásicas / Carcinoma de Pulmón de Células no Pequeñas / Familia-src Quinasas / Factor de Transcripción STAT3 / Neoplasias Pulmonares Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article

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