Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease.

Chen, Guochun; Chen, Huihui; Ren, Shuyu; Xia, Ming; Zhu, Jiefu; Liu, Yu; Zhang, Lei; Tang, Luosheng; Sun, Lin; Liu, Hong; Dong, Zheng

Chen, Guochun; Chen, Huihui; Ren, Shuyu; Xia, Ming; Zhu, Jiefu; Liu, Yu; Zhang, Lei; Tang, Luosheng; Sun, Lin; Liu, Hong; Dong, Zheng.

Afiliación

Chen G; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China. Electronic address: chenguochun@hotmail.com.
Chen H; Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ren S; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Xia M; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhu J; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liu Y; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
Zhang L; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
Tang L; Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sun L; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
Liu H; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China. Electronic address: liuhong618@csu.edu.cn.
Dong Z; Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Nor

Kidney Int ; 96(2): 409-420, 2019 08.

Article en En | MEDLINE | ID: mdl-31101365

Asunto(s)

ADN (Citosina-5-)-Metiltransferasa 1/sangre; Metilación de ADN/inmunología; Nefropatías Diabéticas/inmunología; Leucocitos Mononucleares/inmunología; Transducción de Señal/genética; Adolescente; Traslado Adoptivo; Adulto; Anciano; Animales; Azacitidina/administración & dosificación; Citosina/metabolismo; ADN (Citosina-5-)-Metiltransferasa 1/antagonistas & inhibidores; ADN (Citosina-5-)-Metiltransferasa 1/genética; Nefropatías Diabéticas/sangre; Nefropatías Diabéticas/genética; Nefropatías Diabéticas/terapia; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Epigénesis Genética/efectos de los fármacos; Epigénesis Genética/inmunología; Femenino; Técnicas de Silenciamiento del Gen; Humanos; Leucocitos Mononucleares/metabolismo; Masculino; Ratones; Persona de Mediana Edad; Cultivo Primario de Células; Regiones Promotoras Genéticas/genética; Transducción de Señal/inmunología; Serina-Treonina Quinasas TOR/genética; Serina-Treonina Quinasas TOR/metabolismo; Regulación hacia Arriba/genética; Regulación hacia Arriba/inmunología; Adulto Joven

Palabras clave

DNA methylation; DNA methyltransferase 1; chronic inflammation; diabetic kidney disease; mammalian target of rapamycin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Transducción de Señal / Metilación de ADN / Nefropatías Diabéticas / ADN (Citosina-5-)-Metiltransferasa 1 Idioma: En Revista: Kidney Int Año: 2019 Tipo del documento: Article

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