Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.
Chem Sci
; 10(17): 4673-4683, 2019 May 07.
Article
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| MEDLINE
| ID: mdl-31123578
ABSTRACT
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and 'drug-like' structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.
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Chem Sci
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2019
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Article