Rapid and sensitive LC-MS/MS method for simultaneous quantification of capsaicin and dihydrocapsaicin in microdialysis samples following dermal application.

Lorenzoni, Ricardo; Barreto, Fabiano; Contri, Renata Vidor; de Araújo, Bibiana Verlindo; Pohlman, Adriana Raffin; Costa, Teresa Dalla; Guterres, Silvia Stanisçuaski

Lorenzoni, Ricardo; Barreto, Fabiano; Contri, Renata Vidor; de Araújo, Bibiana Verlindo; Pohlman, Adriana Raffin; Costa, Teresa Dalla; Guterres, Silvia Stanisçuaski.

Afiliación

Lorenzoni R; Pharmaceutical Sciences Graduate Program, College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: ricardolorenzoni@yahoo.com.br.
Barreto F; Laboratório Nacional Agropecuário do Rio Grande do Sul (LANAGRO/RS), Porto Alegre, RS, Brazil. Electronic address: fabiano.barreto@agricultura.gov.br.
Contri RV; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: renata.contri@ufrgs.br.
de Araújo BV; Pharmaceutical Sciences Graduate Program, College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: bibiana.araujo@ufrgs.br.
Pohlman AR; Pharmaceutical Sciences Graduate Program, College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: adriana.pohlmann@ufrgs.br.
Costa TD; Pharmaceutical Sciences Graduate Program, College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: dalla.costa@ufrgs.br.
Guterres SS; Pharmaceutical Sciences Graduate Program, College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; College of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: silvia.guterres@ufrgs.br.

J Pharm Biomed Anal ; 173: 126-133, 2019 Sep 05.

Article en En | MEDLINE | ID: mdl-31129532

Asunto(s)

Capsaicina/análogos & derivados; Capsaicina/análisis; Fármacos del Sistema Sensorial/análisis; Crema para la Piel/análisis; Animales; Capsaicina/administración & dosificación; Capsaicina/farmacocinética; Cromatografía Líquida de Alta Presión/métodos; Dermis/química; Masculino; Microdiálisis/métodos; Modelos Animales; Ratas; Ratas Wistar; Reproducibilidad de los Resultados; Sensibilidad y Especificidad; Fármacos del Sistema Sensorial/administración & dosificación; Fármacos del Sistema Sensorial/farmacocinética; Crema para la Piel/administración & dosificación; Crema para la Piel/farmacocinética; Espectrometría de Masas en Tándem/métodos; Distribución Tisular

Palabras clave

Bioanalytical validation; Capsaicin; Dermal microdialysis; Dihydrocapsaicin; LCMS/MS

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Capsaicina / Fármacos del Sistema Sensorial / Crema para la Piel Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Pharm Biomed Anal Año: 2019 Tipo del documento: Article

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