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A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer.
Bangi, Erdem; Ang, Celina; Smibert, Peter; Uzilov, Andrew V; Teague, Alexander G; Antipin, Yevgeniy; Chen, Rong; Hecht, Chana; Gruszczynski, Nelson; Yon, Wesley J; Malyshev, Denis; Laspina, Denise; Selkridge, Isaiah; Rainey, Hope; Moe, Aye S; Lau, Chun Yee; Taik, Patricia; Wilck, Eric; Bhardwaj, Aarti; Sung, Max; Kim, Sara; Yum, Kendra; Sebra, Robert; Donovan, Michael; Misiukiewicz, Krzysztof; Schadt, Eric E; Posner, Marshall R; Cagan, Ross L.
Afiliación
  • Bangi E; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Ang C; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Smibert P; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Uzilov AV; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Teague AG; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Antipin Y; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Chen R; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Hecht C; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Gruszczynski N; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Yon WJ; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Malyshev D; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Laspina D; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Selkridge I; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Rainey H; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Moe AS; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Lau CY; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Taik P; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Wilck E; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Bhardwaj A; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Sung M; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Kim S; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Yum K; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Sebra R; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Donovan M; SEMA4, a Mount Sinai Venture, 333 Ludlow Street, South Tower, 3rd floor, Stamford, CT 06902, USA.
  • Misiukiewicz K; Department of Radiology, The Mount Sinai Hospital, New York, NY 10029, USA.
  • Schadt EE; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Posner MR; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Cagan RL; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sci Adv ; 5(5): eaav6528, 2019 05.
Article en En | MEDLINE | ID: mdl-31131321
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridonas / Pirimidinonas / Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Genes ras / Ácido Zoledrónico Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Adv Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridonas / Pirimidinonas / Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Genes ras / Ácido Zoledrónico Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Adv Año: 2019 Tipo del documento: Article