Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple HâF Bioisosterism.

Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple HâF Bioisosterism.

Bentler, Patrick; Bergander, Klaus; Daniliuc, Constantin G; Mück-Lichtenfeld, Christian; Jumde, Ravindra P; Hirsch, Anna K H; Gilmour, Ryan.

Afiliación

Bentler P; Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
Bergander K; Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
Daniliuc CG; Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
Mück-Lichtenfeld C; Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
Jumde RP; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Drug Design and Optimization, University Campus E8.1, 66123, Saarbrücken, Germany.
Hirsch AKH; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Drug Design and Optimization, University Campus E8.1, 66123, Saarbrücken, Germany.
Gilmour R; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany.

Angew Chem Int Ed Engl ; 58(32): 10990-10994, 2019 08 05.

Article en En | MEDLINE | ID: mdl-31157945