HTLV-1-host interactions facilitate the manifestations of cardiovascular disease.
Microb Pathog
; 134: 103578, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31175973
ABSTRACT
Atherosclerosis is a multifactorial life-threatening disease which an epidemiologic study in Northeastern Iran showed its association with HTLV-1 infection. Therefore, a cross-sectional study of 39 newly diagnosed subjects with angiography test in three groups including 14 coronary artery disease+HTLV-1+ (CAD+HTLV-1+), 8 CAD-HTLV-1+, and 17 CAD+HTLV-1- patients and 11 healthy subjects (CAD-HTLV-1-) were conducted. In the present study, Tax and proviral load (PVL) as HTLV-1 virulence factors, along with host chemokine receptor 1 (CCR1), and CCR2 were investigated. Real-time PCR TaqMan method was carried out for PVL measurement and HTLV-1-Tax, CCR1, and CCR2 expressions in peripheral blood mononuclear cells (PBMCs). Furthermore, the main risk factors, lipid profile, and complete blood count (CBC) were assessed. Expression of CCR1 in CAD+HTLV-1+ group was higher than CAD-HTLV-1+ (Pâ¯=â¯0.01) and healthy subjects (Pâ¯=â¯0.02). Expression of CCR1 in CAD+HTLV-1+ was higher in comparison with CAD+HTLV-1-group but did not meet 95% CI (Pâ¯=â¯0.02), but meaningful at 91% CI. In addition, expression of CCR2 in CAD+HTLV-1+ subjects was higher than CAD-HTLV-1+ and CAD+HTLV-1- (Pâ¯=â¯0.001, Pâ¯=â¯0.005, respectively). In CAD+HTLV-1- subjects, CCR2 was higher than CAD-HTLV-1+ (Pâ¯=â¯0.03). The mean PVL in CAD+HTLV-1+ group is more than CAD-HTLV-1+ (Pâ¯=â¯0.041). In HTLV-1+ patients Tax had a positive correlation with cholesterol (Râ¯=â¯0.59, Pâ¯=â¯0.01), LDL (Râ¯=â¯0.79, Pâ¯=â¯0.004) and a negative correlation with HDL (Râ¯=â¯-0.47, Pâ¯=â¯0.04). These correlations were stronger in CAD+HTLV-1+. Findings showed that HTLV-1 could alter the expression of CCR2 and, less effect, on CCR1. Moreover, the strong correlation between CCR2 and HTLV-1-Tax with cholesterol, LDL and HDL showed that Tax as the main HTLV-1 virulence factor in cytokine deregulation might be had indirect effects on cholesterol, LDL, and HDL levels.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Microb Pathog
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2019
Tipo del documento:
Article