Engineering D-Lactate Dehydrogenase from Pediococcus acidilactici for Improved Activity on 2-Hydroxy Acids with Bulky C<sub>3</sub> Functional Group.

Lee, Hoe-Suk; Park, Jisu; Yoo, Young Je; Yeon, Young Joo

Engineering D-Lactate Dehydrogenase from Pediococcus acidilactici for Improved Activity on 2-Hydroxy Acids with Bulky C₃ Functional Group.

Lee, Hoe-Suk; Park, Jisu; Yoo, Young Je; Yeon, Young Joo.

Afiliación

Lee HS; Program of Bioengineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Park J; Department of Biochemical Engineering, Gangneung-Wonju National University, 7, Jukheon-gil, Gangneung-si, Gangwon-do, 25457, Republic of Korea.
Yoo YJ; Program of Bioengineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. yjyoo@snu.ac.kr.
Yeon YJ; School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. yjyoo@snu.ac.kr.

Appl Biochem Biotechnol ; 189(4): 1141-1155, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31190286

Asunto(s)

Sustitución de Aminoácidos; Proteínas Bacterianas/química; Biocatálisis; Butiratos/química; Hemiterpenos/química; Cetoácidos/química; L-Lactato Deshidrogenasa/química; Pediococcus acidilactici/enzimología; Proteínas Bacterianas/genética; L-Lactato Deshidrogenasa/genética; Mutación Missense; Pediococcus acidilactici/genética

Palabras clave

2-Hydroxy acids; Computational docking; D-Lactate dehydrogenase; Rational design; Substrate specificity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Butiratos / Sustitución de Aminoácidos / Hemiterpenos / Biocatálisis / Pediococcus acidilactici / Cetoácidos / L-Lactato Deshidrogenasa Idioma: En Revista: Appl Biochem Biotechnol Año: 2019 Tipo del documento: Article

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