Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes.
Nat Prod Res
; 35(10): 1682-1685, 2021 May.
Article
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| MEDLINE
| ID: mdl-31198053
ABSTRACT
Hydro-distilled essential oil from leaves of Xylopia laevigata was characterized by GC-MS. Twenty-seven components were identified and the oil's major constituents comprised germacrene D, bicyclogermacrene, (E)-caryophyllene and germacrene B. The cytotoxicity of the essential oil of X. laevigata (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all tested concentrations. Cultures treated with EOXL demonstrated significant increase in the frequencies of micronuclei in the cytokinesis-block micronucleus assay (CBMN) and reduction of the cytokinesis-block proliferation index (CBPI) rates. Results demonstrated the cytostatic and mutagenic effects of EOXL, the latter for the first time.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Aceites Volátiles
/
Linfocitos
/
Citostáticos
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Xylopia
/
Mutágenos
Idioma:
En
Revista:
Nat Prod Res
Año:
2021
Tipo del documento:
Article