Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan.
Acta Crystallogr F Struct Biol Commun
; 75(Pt 6): 405-411, 2019 Jun 01.
Article
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| MEDLINE
| ID: mdl-31204686
ABSTRACT
Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extracellular domain (residues 55-750) of rabbit neprilysin was solved both in its native form at 2.1â
Å resolution, and bound to the inhibitors phosphoramidon and thiorphan at 2.8 and 3.0â
Å resolution, respectively. Consistent with the extracellular domain of human neprilysin, the structure reveals a large central cavity which contains the active site and the location for inhibitor binding.
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MEDLINE
Asunto principal:
Inhibidores de Proteasas
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Glicopéptidos
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Neprilisina
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Tiorfan
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Modelos Moleculares
Idioma:
En
Revista:
Acta Crystallogr F Struct Biol Commun
Año:
2019
Tipo del documento:
Article