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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion.
Khan, Omar; Giles, Josephine R; McDonald, Sierra; Manne, Sasikanth; Ngiow, Shin Foong; Patel, Kunal P; Werner, Michael T; Huang, Alexander C; Alexander, Katherine A; Wu, Jennifer E; Attanasio, John; Yan, Patrick; George, Sangeeth M; Bengsch, Bertram; Staupe, Ryan P; Donahue, Greg; Xu, Wei; Amaravadi, Ravi K; Xu, Xiaowei; Karakousis, Giorgos C; Mitchell, Tara C; Schuchter, Lynn M; Kaye, Jonathan; Berger, Shelley L; Wherry, E John.
Afiliación
  • Khan O; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Giles JR; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • McDonald S; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Manne S; Arsenal Biosciences, South San Francisco, CA, USA.
  • Ngiow SF; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Patel KP; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Werner MT; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang AC; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Alexander KA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wu JE; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Attanasio J; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Yan P; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • George SM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bengsch B; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Staupe RP; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Donahue G; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Xu W; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Amaravadi RK; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Xu X; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Karakousis GC; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Mitchell TC; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Schuchter LM; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kaye J; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Berger SL; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wherry EJ; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature ; 571(7764): 211-218, 2019 07.
Article en En | MEDLINE | ID: mdl-31207603
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transcripción Genética / Proteínas de Homeodominio / Linfocitos T CD8-positivos / Epistasis Genética Tipo de estudio: Prognostic_studies Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transcripción Genética / Proteínas de Homeodominio / Linfocitos T CD8-positivos / Epistasis Genética Tipo de estudio: Prognostic_studies Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article