Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery.
Diabetes Care
; 42(7): 1344-1347, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31221700
ABSTRACT
OBJECTIVE:
To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN ANDMETHODS:
We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 15), and adults (>18 years, n = 58) with type 1 diabetes. The coefficient of variation quantified variability of insulin needs during 3 weeks of unrestricted-living hybrid closed-loop use.RESULTS:
Data from 2,365 nights and 2,367 days in 114 participants were analyzed. The coefficient of variation of insulin delivery was higher in young children compared with adults (mean difference at nighttime 10.7 percentage points [95% CI 2.9-18.4], P = 0.003; daytime 6.4 percentage points [95% CI 2.0-10.9], P = 0.002) and compared with adolescents (mean difference at nighttime 10.2 percentage points [95% CI 0.0-20.4], P = 0.049; daytime 7.0 percentage points [95% CI 1.1-12.8], P = 0.014).CONCLUSIONS:
Diabetes management in young children is complicated by higher variability in insulin requirements, supporting fast-track clinical practice adoption of closed-loop in this vulnerable population.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sistemas de Infusión de Insulina
/
Diabetes Mellitus Tipo 1
/
Insulina
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Diabetes Care
Año:
2019
Tipo del documento:
Article