Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in <i>Caenorhabditis elegans</i>.

Williams, Ashley B; Heider, Felix; Messling, Jan-Erik; Rieckher, Matthias; Bloch, Wilhelm; Schumacher, Björn

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans.

Williams, Ashley B; Heider, Felix; Messling, Jan-Erik; Rieckher, Matthias; Bloch, Wilhelm; Schumacher, Björn.

Afiliación

Williams AB; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.
Heider F; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Germany.
Messling JE; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Germany.
Rieckher M; Systems Biology of Ageing Cologne, University of Cologne, 50931, Germany.
Bloch W; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.
Schumacher B; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Germany.

Genetics ; 212(4): 1259-1278, 2019 08.

Article en En | MEDLINE | ID: mdl-31248887

Asunto(s)

ADN/inmunología; Retículo Endoplásmico/metabolismo; Inmunidad Innata; Proteostasis; Animales; Caenorhabditis elegans; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Endodesoxirribonucleasas/genética; Endodesoxirribonucleasas/metabolismo

Palabras clave

Caenorhabditis elegans; DNA sensing; DNase II; inflammatory responses; innate immunity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ADN / Retículo Endoplásmico / Proteostasis / Inmunidad Innata Idioma: En Revista: Genetics Año: 2019 Tipo del documento: Article

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