Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization.
J Allergy Clin Immunol
; 144(6): 1638-1647.e3, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31279007
ABSTRACT
BACKGROUND:
Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance.OBJECTIVE:
We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children.METHODS:
We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, before their developing allergic disease.RESULTS:
We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production.CONCLUSIONS:
Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Ácido Butírico
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Disbiosis
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Microbioma Gastrointestinal
/
Hipersensibilidad
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2019
Tipo del documento:
Article