Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease.
Neurobiol Aging
; 81: 138-145, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31280117
ABSTRACT
The regional relationships between tau positron emission tomography (PET) imaging and cognitive impairment in Alzheimer's disease (AD) remain uncertain. We examined cross-sectional associations between cognitive performance, cerebral uptake of the novel tau PET tracer [18F]GTP1, and other neuroimaging indices ([18F]florbetapir amyloid PET, magnetic resonance imaging) in 71 participants with normal cognition, prodromal AD, or AD dementia. Greater [18F]GTP1 uptake was seen with increasing clinical severity and correlated with poorer cognition. [18F]GTP1 uptake and cortical volume (but not [18F]florbetapir uptake) were independently associated with cognitive performance, particularly within the temporal lobe. Delayed memory was more specifically associated with temporal [18F]GTP1 uptake; other domains correlated with a broader range of regional [18F]GTP1 uptake. These data confirm that [18F]GTP1 tau PET uptake significantly correlates with cognitive performance in AD, but regional correlations between performance in non-memory cognitive domains were less specific than reported by tau PET imaging studies that included participants with atypical focal cortical AD syndromes. Tau PET imaging may have utility as a surrogate biomarker for clinical AD progression in therapeutic trials of disease-modifying interventions.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Radioisótopos de Flúor
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Proteínas tau
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Cognición
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Radiofármacos
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Tomografía de Emisión de Positrones
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Enfermedad de Alzheimer
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Disfunción Cognitiva
Tipo de estudio:
Observational_studies
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Prevalence_studies
Idioma:
En
Revista:
Neurobiol Aging
Año:
2019
Tipo del documento:
Article