Isotonic versus Hypotonic Intravenous Maintenance Fluids in Children: A Randomized Controlled Trial.
Indian J Pediatr
; 86(11): 1011-1016, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31280410
ABSTRACT
OBJECTIVE:
To compare the incidence of hyponatremia during the first 48 h in hospitalized children receiving normal saline vs. N/2 saline as maintenance intravenous fluid.METHODS:
This open label, randomized controlled trial to compare the incidence of hyponatremia in hospitalized children receiving normal saline (0.9% sodium chloride in 5% dextrose) vs. N/2 saline (0.45% sodium chloride in 5% dextrose) as maintenance fluid was conducted from December 2014 through November 2015 in a tertiary care teaching hospital. Children between 1 mo and 18 y requiring maintenance intravenous fluids were randomized to receive normal saline with 5% dextrose (n = 75) or N/2 saline with 5% dextrose (n = 75).RESULTS:
Both groups were comparable for demographic variables and illness severity at baseline. Incidence of hyponatremia at 24 h of hospitalization was comparable between normal saline and N/2 saline group, 3(4%) vs. 6(8%) cases, respectively; p value 0.494. Mean serum sodium levels were marginally higher in normal saline group (138.3 ± 6.0 mEq/L) as compared with N/2 saline group (135.1 ± 4.4 mEq/L) (p value <0.01) at 24 h of hospitalization. Incidence of hyponatremia at 48 h and hypernatremia at 24 and 48 h was comparable in two groups.CONCLUSIONS:
The use of either N/2 saline or normal saline in sick children at standard maintenance fluid rates is associated with low but comparable incidence of hypo or hypernatremia in first 24 h of hospitalization. Both types of fluids appear acceptable in hospitalized sick children.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infusiones Intravenosas
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Hiponatremia
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Soluciones Hipotónicas
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Soluciones Isotónicas
Tipo de estudio:
Clinical_trials
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Incidence_studies
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Prognostic_studies
Idioma:
En
Revista:
Indian J Pediatr
Año:
2019
Tipo del documento:
Article