Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions.
Nat Prod Rep
; 37(1): 17-28, 2020 01 01.
Article
en En
| MEDLINE
| ID: mdl-31290896
ABSTRACT
Covering 2012 to 2019HemN-like radical S-adenosyl-l-methionine (SAM) enzymes have been recently disclosed to catalyze diverse chemically challenging reactions from primary to secondary metabolic pathways. In this highlight, we summarize the reaction examples catalyzed by HemN-like enzymes to date and the enzymatic mechanisms reported. From the recent mechanistic investigations, we reason that there is a shared initiating mechanism wherein a characteristic SAM methylene radical is proposed to abstract a hydrogen atom from an sp3 carbon or add onto an sp2 carbon center although variations occur thereafter from reaction to reaction, as well as providing a brief insight into some future prospects.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
S-Adenosilmetionina
/
Enzimas
Idioma:
En
Revista:
Nat Prod Rep
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article