Simple 3D printed stainless steel microreactors for online mass spectrometric analysis.

Scotti, Gianmario; Nilsson, Sofia M E; Matilainen, Ville-Pekka; Haapala, Markus; Boije Af Gennäs, Gustav; Yli-Kauhaluoma, Jari; Salminen, Antti; Kotiaho, Tapio

Scotti, Gianmario; Nilsson, Sofia M E; Matilainen, Ville-Pekka; Haapala, Markus; Boije Af Gennäs, Gustav; Yli-Kauhaluoma, Jari; Salminen, Antti; Kotiaho, Tapio.

Afiliación

Scotti G; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Nilsson SME; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Matilainen VP; Laser Processing Research Group, Lappeenranta University of Technology, Tuotantokatu 2, FI-53850, Lappeenranta, Finland.
Haapala M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Boije Af Gennäs G; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.
Salminen A; Laser Processing Research Group, Lappeenranta University of Technology, Tuotantokatu 2, FI-53850, Lappeenranta, Finland.
Kotiaho T; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland.

Heliyon ; 5(7): e02002, 2019 Jul.

Article en En | MEDLINE | ID: mdl-31312730

ABSTRACT

ABSTRACT

A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.

Palabras clave

3D printing; Analytical chemistry; Mass spectrometry; Microreactor; Organic chemistry; Reaction monitoring; Stainless steel

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