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LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
Qile, Muge; Beekman, Henriette D M; Sprenkeler, David J; Houtman, Marien J C; van Ham, Willem B; Stary-Weinzinger, Anna; Beyl, Stanislav; Hering, Steffen; van den Berg, Dirk-Jan; de Lange, Elizabeth C M; Heitman, Laura H; IJzerman, Ad P; Vos, Marc A; van der Heyden, Marcel A G.
Afiliación
  • Qile M; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Beekman HDM; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Sprenkeler DJ; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Houtman MJC; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • van Ham WB; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Stary-Weinzinger A; Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
  • Beyl S; Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
  • Hering S; Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
  • van den Berg DJ; Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
  • de Lange ECM; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Heitman LH; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Vos MA; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • van der Heyden MAG; Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Br J Pharmacol ; 176(19): 3871-3885, 2019 10.
Article en En | MEDLINE | ID: mdl-31339551
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridinas / Torsades de Pointes / Modelos Animales de Enfermedad / Bloqueo Atrioventricular / Canal de Potasio ERG1 / Antiarrítmicos Idioma: En Revista: Br J Pharmacol Año: 2019 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridinas / Torsades de Pointes / Modelos Animales de Enfermedad / Bloqueo Atrioventricular / Canal de Potasio ERG1 / Antiarrítmicos Idioma: En Revista: Br J Pharmacol Año: 2019 Tipo del documento: Article