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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Wang, Heming; Lane, Jacqueline M; Jones, Samuel E; Dashti, Hassan S; Ollila, Hanna M; Wood, Andrew R; van Hees, Vincent T; Brumpton, Ben; Winsvold, Bendik S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G; Bechtold, David A; Bowden, Jack; Emsley, Richard; Kyle, Simon D; Little, Max A; Loudon, Andrew S; Scheer, Frank A J L; Purcell, Shaun M; Richmond, Rebecca C; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B; Willer, Cristen J; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M; Ray, David; Lawlor, Deborah A; Rutter, Martin K; Weedon, Michael N; Redline, Susan; Saxena, Richa.
Afiliación
  • Wang H; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Lane JM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Jones SE; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Dashti HS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Ollila HM; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
  • van Hees VT; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Brumpton B; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Winsvold BS; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Kantojärvi K; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Palviainen T; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Cade BE; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
  • Sofer T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Song Y; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
  • Patel K; Netherlands eScience Center, Amsterdam, Netherlands.
  • Anderson SG; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
  • Bechtold DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Bowden J; Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Emsley R; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
  • Kyle SD; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Little MA; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
  • Loudon AS; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Scheer FAJL; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
  • Purcell SM; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Richmond RC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Spiegelhalder K; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Tyrrell J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Zhu X; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Hublin C; Northeastern University College of Science, Boston, MA, USA.
  • Kaprio JA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kristiansson K; Northeastern University College of Science, Boston, MA, USA.
  • Sulkava S; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
  • Paunio T; The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados.
  • Hveem K; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Nielsen JB; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Willer CJ; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Zwart JA; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Strand LB; Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Frayling TM; Department of Mathematics, Aston University, Birmingham, UK.
  • Ray D; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lawlor DA; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Rutter MK; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Weedon MN; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Saxena R; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Nat Commun ; 10(1): 3503, 2019 08 13.
Article en En | MEDLINE | ID: mdl-31409809
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sueño / Sitios Genéticos / Somnolencia Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sueño / Sitios Genéticos / Somnolencia Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article