Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.
Pregnancy Hypertens
; 17: 209-215, 2019 Jul.
Article
en En
| MEDLINE
| ID: mdl-31487643
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the relationship between endogenous CYP3A markers and plasma amlodipine (AML) exposure and metabolism parameters in early postpartum and non-peripartum women.METHODS:
Twenty-four AML-treated early postpartum women with hypertensive disorders of pregnancy and 30 non-peripartum women with essential hypertension were enrolled. Blood samples for determination of CYP3A markers including total cholesterol-adjusted 4ß-hydroxycholesterol (4ß-OHC/TC), 25-hydroxyvitamin D (25-OHD), and AML and its metabolites in plasma were collected at 24â¯h after the AML treatment.RESULTS:
The plasma 4ß-OHC/TC in postpartum women was higher than that in non-peripartum women, while the plasma 25-OHD was lower. The postpartum women had a lower plasma AML concentration and its metabolic ratio was higher. The plasma 4ß-OHC/TC decreased as the number of days post-delivery increased. The plasma AML concentration increased as the number of days post-delivery increased, while the metabolic ratio of AML declined slightly. Tendency toward negative correlations between the plasma 4ß-OHC/TC but not 25-OHD, and AML concentration were observed in both postpartum and non-peripartum women. In both groups, the plasma 4ß-OHC/TC was correlated with the metabolic ratio of AML.CONCLUSIONS:
The early postpartum women had higher plasma 4ß-OHC and AML metabolism. The plasma 4ß-OHC had positive relationships with amlodipine metabolism in both women groups. AML metabolism and plasma 4ß-OHC may be useful as CYP3A markers in early postpartum and non-peripartum women.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
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Complicaciones Cardiovasculares del Embarazo
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Amlodipino
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Citocromo P-450 CYP3A
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Hipertensión
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Antihipertensivos
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Pregnancy Hypertens
Año:
2019
Tipo del documento:
Article