Comprehensive autophagy evaluation in cardiac disease models.
Cardiovasc Res
; 116(3): 483-504, 2020 03 01.
Article
en En
| MEDLINE
| ID: mdl-31504266
ABSTRACT
Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Cardiopatías
/
Mitocondrias Cardíacas
/
Miocardio
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Cardiovasc Res
Año:
2020
Tipo del documento:
Article