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Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression.
Tsankov, Alexander M; Wadsworth, Marc H; Akopian, Veronika; Charlton, Jocelyn; Allon, Samuel J; Arczewska, Aleksandra; Mead, Benjamin E; Drake, Riley S; Smith, Zachary D; Mikkelsen, Tarjei S; Shalek, Alex K; Meissner, Alexander.
Afiliación
  • Tsankov AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA alexander.tsankov@mssm.edu shalek@mit.edu meissner@molgen.mpg.de.
  • Wadsworth MH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Akopian V; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Charlton J; Institute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Allon SJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Arczewska A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Mead BE; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Drake RS; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
  • Smith ZD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Mikkelsen TS; Institute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Shalek AK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Meissner A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Development ; 146(19)2019 09 12.
Article en En | MEDLINE | ID: mdl-31515224
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Transcripción Genética / ADN (Citosina-5-)-Metiltransferasas / Células Madre Embrionarias Humanas / ADN (Citosina-5-)-Metiltransferasa 1 Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2019 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Transcripción Genética / ADN (Citosina-5-)-Metiltransferasas / Células Madre Embrionarias Humanas / ADN (Citosina-5-)-Metiltransferasa 1 Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2019 Tipo del documento: Article