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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Juvvadi, Praveen R; Fox, David; Bobay, Benjamin G; Hoy, Michael J; Gobeil, Sophie M C; Venters, Ronald A; Chang, Zanetta; Lin, Jackie J; Averette, Anna Floyd; Cole, D Christopher; Barrington, Blake C; Wheaton, Joshua D; Ciofani, Maria; Trzoss, Michael; Li, Xiaoming; Lee, Soo Chan; Chen, Ying-Lien; Mutz, Mitchell; Spicer, Leonard D; Schumacher, Maria A; Heitman, Joseph; Steinbach, William J.
Afiliación
  • Juvvadi PR; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. praveen.juvvadi@duke.edu.
  • Fox D; Beryllium Discovery Corp., 7869 NE Day Road West, Bainbridge Island, WA, 98110, USA.
  • Bobay BG; UCB Pharma., 7869 NE Day Road West, Bainbridge Island, WA, 98110, USA.
  • Hoy MJ; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA.
  • Gobeil SMC; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA.
  • Venters RA; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.
  • Chang Z; Department of Radiology, Duke University, Durham, NC, 27710, USA.
  • Lin JJ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Averette AF; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.
  • Cole DC; Department of Radiology, Duke University, Durham, NC, 27710, USA.
  • Barrington BC; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA.
  • Wheaton JD; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.
  • Ciofani M; Department of Radiology, Duke University, Durham, NC, 27710, USA.
  • Trzoss M; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Li X; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Lee SC; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Chen YL; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA.
  • Mutz M; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA.
  • Spicer LD; Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Schumacher MA; Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Heitman J; Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA, 92121, USA.
  • Steinbach WJ; Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Nat Commun ; 10(1): 4275, 2019 09 19.
Article en En | MEDLINE | ID: mdl-31537789
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Tacrolimus / Calcineurina / Cryptococcus neoformans / Proteína 1A de Unión a Tacrolimus / Inhibidores de la Calcineurina / Antifúngicos Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Tacrolimus / Calcineurina / Cryptococcus neoformans / Proteína 1A de Unión a Tacrolimus / Inhibidores de la Calcineurina / Antifúngicos Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article