<i>Mycobacterium tuberculosis</i> topoisomerases and EthR as the targets for new anti-TB drugs development.

Sawicki, Rafal; Ginalska, Grazyna

Mycobacterium tuberculosis topoisomerases and EthR as the targets for new anti-TB drugs development.

Sawicki, Rafal; Ginalska, Grazyna.

Afiliación

Sawicki R; Department of Biochemistry & Biotechnology, Medical University of Lublin, Chair, Chodzki 1, PL-20093 Lublin, Poland.
Ginalska G; Department of Biochemistry & Biotechnology, Medical University of Lublin, Chair, Chodzki 1, PL-20093 Lublin, Poland.

Future Med Chem ; 11(16): 2193-2203, 2019 08.

Article en En | MEDLINE | ID: mdl-31538522

Asunto(s)

Antituberculosos/farmacología; Proteínas Bacterianas/antagonistas & inhibidores; Mycobacterium tuberculosis/efectos de los fármacos; Proteínas Represoras/antagonistas & inhibidores; Inhibidores de Topoisomerasa/farmacología; Tuberculosis/tratamiento farmacológico; Animales; Antituberculosos/química; Antituberculosos/uso terapéutico; Proteínas Bacterianas/metabolismo; ADN-Topoisomerasas/metabolismo; Desarrollo de Medicamentos; Humanos; Mycobacterium tuberculosis/metabolismo; Proteínas Represoras/metabolismo; Inhibidores de Topoisomerasa/química; Inhibidores de Topoisomerasa/uso terapéutico; Tuberculosis/microbiología

Palabras clave

drug target; ethionamide; fluoroquinolone; high-throughput screening; in silico docking; molecular hybridization; tuberculosis drug discovery

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Proteínas Bacterianas / Tuberculosis / Inhibidores de Topoisomerasa / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Future Med Chem Año: 2019 Tipo del documento: Article

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