Reshaping Prostate Tumor Microenvironment To Suppress Metastasis <i>via</i> Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem.

Lang, Jiayan; Zhao, Xiao; Qi, Yingqiu; Zhang, Yinlong; Han, Xuexiang; Ding, Yanping; Guan, Jiajing; Ji, Tianjiao; Zhao, Ying; Nie, Guangjun

Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem.

Lang, Jiayan; Zhao, Xiao; Qi, Yingqiu; Zhang, Yinlong; Han, Xuexiang; Ding, Yanping; Guan, Jiajing; Ji, Tianjiao; Zhao, Ying; Nie, Guangjun.

Afiliación

Lang J; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , China.
Zhao X; Center of Materials Science and Optoelectronics Engineering , University of Chinese Academy of Sciences , Beijing 100049 , China.
Qi Y; Sino-Danish Center for Education and Research , Sino-Danish College of UCAS , Beijing 100190 , China.
Zhang Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , China.
Han X; Center of Materials Science and Optoelectronics Engineering , University of Chinese Academy of Sciences , Beijing 100049 , China.
Ding Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , China.
Guan J; School of Basic Medical Sciences , Zhengzhou University , Henan 450001 , China.
Ji T; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , China.
Zhao Y; Center of Materials Science and Optoelectronics Engineering , University of Chinese Academy of Sciences , Beijing 100049 , China.
Nie G; CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , China.

ACS Nano ; 13(11): 12357-12371, 2019 11 26.

Article en En | MEDLINE | ID: mdl-31545587

Asunto(s)

Fibroblastos Asociados al Cáncer; Nanomedicina/métodos; Neoplasias de la Próstata; Microambiente Tumoral; Animales; Fibroblastos Asociados al Cáncer/efectos de los fármacos; Fibroblastos Asociados al Cáncer/metabolismo; Péptidos de Penetración Celular/química; Péptidos de Penetración Celular/farmacología; Quimiocina CXCL12/genética; Quimiocina CXCL12/metabolismo; Endopeptidasas; Gelatinasas/antagonistas & inhibidores; Gelatinasas/metabolismo; Silenciador del Gen; Células Endoteliales de la Vena Umbilical Humana; Humanos; Masculino; Proteínas de la Membrana/antagonistas & inhibidores; Proteínas de la Membrana/metabolismo; Ratones Endogámicos BALB C; Ratones Desnudos; Nanopartículas/química; Metástasis de la Neoplasia/prevención & control; Células PC-3; Neoplasias de la Próstata/metabolismo; Neoplasias de la Próstata/patología; ARN Interferente Pequeño; Serina Endopeptidasas/metabolismo; Microambiente Tumoral/efectos de los fármacos; Microambiente Tumoral/fisiología

Palabras clave

CXCL12 gene silencing; cancer-associated fibroblast inactivation; metastasis inhibition; peptide assembly; prostate cancer

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Nanomedicina / Microambiente Tumoral / Fibroblastos Asociados al Cáncer Tipo de estudio: Risk_factors_studies Idioma: En Revista: ACS Nano Año: 2019 Tipo del documento: Article

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