Regulated spindle orientation buffers tissue growth in the epidermis.
Elife
; 82019 10 02.
Article
en En
| MEDLINE
| ID: mdl-31577227
ABSTRACT
Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle orientation/asymmetric cell divisions is one mechanism that is used to buffer changes in proliferation and tissue turnover in mammalian skin. Genetic and pharmacologic experiments demonstrate that asymmetric cell divisions were increased in hyperproliferative conditions and decreased under hypoproliferative conditions. Further, active K-Ras also increased the frequency of asymmetric cell divisions. Disruption of spindle orientation in combination with constitutively active K-Ras resulted in massive tissue overgrowth. Together, these data highlight the essential roles of spindle orientation in buffering tissue homeostasis in response to perturbations.
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Base de datos:
MEDLINE
Asunto principal:
División Celular
/
Proteínas Proto-Oncogénicas p21(ras)
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Proliferación Celular
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División Celular Asimétrica
Idioma:
En
Revista:
Elife
Año:
2019
Tipo del documento:
Article