Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aß Oligomerization in Vitro and Aß Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer's Disease.

Tomaselli, Simona; La Vitola, Pietro; Pagano, Katiuscia; Brandi, Edoardo; Santamaria, Giulia; Galante, Denise; D'Arrigo, Cristina; Moni, Lisa; Lambruschini, Chiara; Banfi, Luca; Lucchetti, Jacopo; Fracasso, Claudia; Molinari, Henriette; Forloni, Gianluigi; Balducci, Claudia; Ragona, Laura

Tomaselli, Simona; La Vitola, Pietro; Pagano, Katiuscia; Brandi, Edoardo; Santamaria, Giulia; Galante, Denise; D'Arrigo, Cristina; Moni, Lisa; Lambruschini, Chiara; Banfi, Luca; Lucchetti, Jacopo; Fracasso, Claudia; Molinari, Henriette; Forloni, Gianluigi; Balducci, Claudia; Ragona, Laura.

Afiliación

Tomaselli S; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Milan 20133 , Italy.
La Vitola P; Department of Neuroscience , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Pagano K; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Milan 20133 , Italy.
Brandi E; Department of Neuroscience , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Santamaria G; Department of Neuroscience , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Galante D; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Genoa 16149 , Italy.
D'Arrigo C; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Genoa 16149 , Italy.
Moni L; Department of Chemistry and Industrial Chemistry , Università di Genova , Genova 16146 , Italy.
Lambruschini C; Department of Chemistry and Industrial Chemistry , Università di Genova , Genova 16146 , Italy.
Banfi L; Department of Chemistry and Industrial Chemistry , Università di Genova , Genova 16146 , Italy.
Lucchetti J; Department of Molecular Biochemistry and Pharmacology , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Fracasso C; Department of Molecular Biochemistry and Pharmacology , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Molinari H; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Milan 20133 , Italy.
Forloni G; Department of Neuroscience , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Balducci C; Department of Neuroscience , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milan 20156 , Italy.
Ragona L; Istituto per lo Studio delle Macromolecole (ISMAC), CNR , Milan 20133 , Italy.

ACS Chem Neurosci ; 10(11): 4462-4475, 2019 11 20.

Article en En | MEDLINE | ID: mdl-31603646

Asunto(s)

Enfermedad de Alzheimer/inducido químicamente; Enfermedad de Alzheimer/tratamiento farmacológico; Péptidos beta-Amiloides/toxicidad; Modelos Animales de Enfermedad; Trastornos de la Memoria/inducido químicamente; Trastornos de la Memoria/tratamiento farmacológico; Fragmentos de Péptidos/toxicidad; Polifenoles/uso terapéutico; Enfermedad Aguda; Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/química; Animales; Células Cultivadas; Inflamación/inducido químicamente; Inflamación/tratamiento farmacológico; Inflamación/metabolismo; Trastornos de la Memoria/metabolismo; Ratones; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular/métodos; Fragmentos de Péptidos/química; Polifenoles/química; Estructura Secundaria de Proteína

Palabras clave

NMR; animal model; docking; inflammation; memory; polyphenols; ß-Amyloid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Modelos Animales de Enfermedad / Enfermedad de Alzheimer / Polifenoles / Trastornos de la Memoria Idioma: En Revista: ACS Chem Neurosci Año: 2019 Tipo del documento: Article

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