Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.

Taniguchi, Mariko; Miyamoto, Hirotaka; Tokunaga, Ayako; Fumoto, Shintaro; Tanaka, Takashi; Nishida, Koyo

Taniguchi, Mariko; Miyamoto, Hirotaka; Tokunaga, Ayako; Fumoto, Shintaro; Tanaka, Takashi; Nishida, Koyo.

Afiliación

Taniguchi M; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Miyamoto H; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Tokunaga A; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Fumoto S; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Tanaka T; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Nishida K; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

Xenobiotica ; 50(6): 654-662, 2020 Jun.

Article en En | MEDLINE | ID: mdl-31631733

Asunto(s)

Acetaminofén/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; ARN Mensajero/metabolismo; Acetaminofén/toxicidad; Enfermedad Hepática Inducida por Sustancias y Drogas/genética; Receptor de Androstano Constitutivo; Citocromo P-450 CYP2E1/metabolismo; Células Hep G2; Hepatocitos/metabolismo; Humanos; Inactivación Metabólica; Hígado; Tasa de Depuración Metabólica; Receptores Citoplasmáticos y Nucleares

Palabras clave

Acetaminophen-induced hepatotoxicity; constitutive androstane receptor; cytochrome P450; pregnane X receptor; reactive oxygen species; three-dimensional cell model

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN Mensajero / Enfermedad Hepática Inducida por Sustancias y Drogas / Acetaminofén Idioma: En Revista: Xenobiotica Año: 2020 Tipo del documento: Article

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