Incidence trends and survival prediction of hepatoblastoma in children: a population-based study.
Cancer Commun (Lond)
; 39(1): 62, 2019 10 24.
Article
en En
| MEDLINE
| ID: mdl-31651371
ABSTRACT
BACKGROUND:
Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children. Due to limited epidemiological data, therapy for hepatoblastoma tends to be individualized. This study aimed to evaluate incidence trends of hepatoblastoma and to develop a nomogram to predict the survival of children with newly diagnosed hepatoblastoma on a population-based level.METHODS:
Individuals up to 18 years of age with hepatoblastoma recorded in 18 registries of the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015 were examined. Joinpoint regression analyses were applied to assess incidence trends in annual percentage change (APC). Multivariable Cox regression was used to identify factors associated with overall survival (OS). A nomogram was constructed to predict OS in individual cases based on independent predictors. Concordance index (C-index) and calibration curves were used to evaluate predictive performance.RESULTS:
Between 2004 and 2015, hepatoblastoma incidence increased significantly (APC, 2.2%; 95% confidence interval [CI] 0.5% to 3.8%, P < 0.05). In particular, this increase was observed among 2- to 4-year-old patients, males, and African-Americans. The 5- and 10-year OS rates were 81.5% and 81.0%, respectively. Age of 2 to 4 years, African-American ethnicity, and no surgery were independent predictors for short OS. Distant disease at presentation was found not to be an independent factor of survival. The nomogram had a C-index of 0.79 (95% CI 0.74-0.84) with appropriate calibration curve fitting.CONCLUSIONS:
We constructed a nomogram that integrates common factors associated with survival for hepatoblastoma patients. It provides accurate prognostic prediction for children with hepatoblastoma.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Hepatoblastoma
/
Neoplasias Hepáticas
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Cancer Commun (Lond)
Año:
2019
Tipo del documento:
Article