A New Sequence Type of Neisseria meningitidis Serogroup C Associated With a 2016 Meningitis Outbreak in Mali.
J Infect Dis
; 220(220 Suppl 4): S190-S197, 2019 10 31.
Article
en En
| MEDLINE
| ID: mdl-31671437
ABSTRACT
In 2016, Mali reported a bacterial meningitis outbreak consisting of 39 suspected cases between epidemiologic weeks 9 and 17 with 15% case fatality ratio in the health district of Ouéléssebougou, 80 kilometers from the capital Bamako. Cerebrospinal fluid specimens from 29 cases were tested by culture and real-time polymerase chain reaction; 22 (76%) were positive for bacterial meningitis pathogens, 16 (73%) of which were Neisseria meningitidis (Nm). Of the Nm-positive specimens, 14 (88%) were N meningitidis serogroup C (NmC), 1 was NmW, and 1 was nongroupable. Eight NmC isolates recovered by culture from the outbreak were characterized using whole genome sequencing. Genomics analysis revealed that all 8 isolates belonged to a new sequence type (ST) 12446 of clonal complex 10217 that formed a distinct clade genetically similar to ST-10217, a NmC strain that recently caused large epidemics of meningitis in Niger and Nigeria. The emergence of a new ST of NmC associated with an outbreak in the African meningitis belt further highlights the need for continued molecular surveillance in the region.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Brotes de Enfermedades
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Neisseria meningitidis Serogrupo C
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Genotipo
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Meningitis Meningocócica
Tipo de estudio:
Diagnostic_studies
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Risk_factors_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Año:
2019
Tipo del documento:
Article