Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth.
Phytochemistry
; 169: 112185, 2020 Jan.
Article
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| MEDLINE
| ID: mdl-31678786
ABSTRACT
Seven new acylated iridoid glycosides, picrorhizaosides A-G (1-7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to six known iridoid glycosides (8-13). The structures of these new iridoids, including their stereochemistry, were determined based on chemical and physicochemical evidence derived from NMR and MS analysis. Of the isolates, picrorhizaosides D (4, IC50â¯=â¯43.4⯵M) and E (5, 35.8⯵M); picrosides I (8, 60.7⯵M), II (9, 22.3⯵M), and IV (11, 59.2⯵M); and minecoside (13, 57.2⯵M), exhibited a similar or stronger hyaluronidase inhibitory activity than those of the antiallergic medicines disodium cromoglycate (64.8⯵M), ketotifen fumarate (76.5⯵M), and tranilast (227⯵M).
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Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Rizoma
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Picrorhiza
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Inhibidores Enzimáticos
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Glicósidos Iridoides
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Hialuronoglucosaminidasa
Idioma:
En
Revista:
Phytochemistry
Año:
2020
Tipo del documento:
Article