Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas.

Lei, Hui-Min; Zhang, Ke-Ren; Wang, Cong Hui; Wang, Yang; Zhuang, Guang-Lei; Lu, Li-Ming; Zhang, Jian; Shen, Ying; Chen, Hong-Zhuan; Zhu, Liang

Lei, Hui-Min; Zhang, Ke-Ren; Wang, Cong Hui; Wang, Yang; Zhuang, Guang-Lei; Lu, Li-Ming; Zhang, Jian; Shen, Ying; Chen, Hong-Zhuan; Zhu, Liang.

Afiliación

Lei HM; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhang KR; Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai, 200025, China.
Wang CH; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang Y; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhuang GL; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Lu LM; State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Zhang J; Central laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Shen Y; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Chen HZ; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhu L; Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai, 200025, China.

Theranostics ; 9(24): 7122-7139, 2019.

Article en En | MEDLINE | ID: mdl-31695757

Asunto(s)

Adenocarcinoma del Pulmón/tratamiento farmacológico; Adenocarcinoma del Pulmón/enzimología; Familia de Aldehído Deshidrogenasa 1/metabolismo; Resistencia a Antineoplásicos; Clorhidrato de Erlotinib/uso terapéutico; Neoplasias Pulmonares/tratamiento farmacológico; Redes y Vías Metabólicas; Especies Reactivas de Oxígeno/metabolismo; Retinal-Deshidrogenasa/metabolismo; Animales; Línea Celular Tumoral; Resistencia a Antineoplásicos/efectos de los fármacos; Transición Epitelial-Mesenquimal/efectos de los fármacos; Clorhidrato de Erlotinib/farmacología; Humanos; Neoplasias Pulmonares/enzimología; Redes y Vías Metabólicas/efectos de los fármacos; Ratones Endogámicos BALB C; Ratones Desnudos; Células Madre Neoplásicas/efectos de los fármacos; Células Madre Neoplásicas/metabolismo; Células Madre Neoplásicas/patología

Palabras clave

ALDH; erlotinib resistance; lung cancer.; reactive carbonyl species; reactive oxygen species

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Resistencia a Antineoplásicos / Retinal-Deshidrogenasa / Redes y Vías Metabólicas / Clorhidrato de Erlotinib / Adenocarcinoma del Pulmón / Familia de Aldehído Deshidrogenasa 1 / Neoplasias Pulmonares Idioma: En Revista: Theranostics Año: 2019 Tipo del documento: Article

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