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N-acetylgalactosamine-6-sulfatase (GALNS), Similar to Glycodelin, Is a Potential General Biomarker for Multiple Malignancies.
Ho, Ming-Lung; Kuo, Wei-Ke; Chu, Lichieh J; Yeh, I-Hsin; Fan, Chung-Wei; Chang, Hsin-I; Yuan, Cho-Li; Chou, Ting-Yu; Chen, Hoang-Yang; Yang, Shih-Wei; Chang, Liang-Che; Luo, Minzhen; Wu, Timothy H; Chang, Yi-Feng I; Yu, Chia-Jung; Hua, Chung-Ching; Ng, Wailap V.
Afiliación
  • Ho ML; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Kuo WK; Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Chu LJ; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Yeh IH; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Fan CW; Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan, R.O.C.
  • Chang HI; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Yuan CL; Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Chou TY; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Chen HY; Liver Research Unit, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Yang SW; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Chang LC; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Luo M; Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Wu TH; Department of Pathology, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Chang YI; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Yu CJ; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
  • Hua CC; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, R.O.C.
  • Ng WV; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, R.O.C.
Anticancer Res ; 39(11): 6317-6324, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31704862
ABSTRACT
BACKGROUND/

AIM:

The aim of this study was to evaluate N-acetylgalactosamine-6-sulfatase (GALNS) as a new biomarker candidate for detecting lung cancer. Glycodelin or PAEP, the serum levels of which are known to be elevated in lung and other cancers, served as a benchmark for comparison. PATIENTS AND

METHODS:

A total of 170 serum samples from healthy controls and patients with pneumonia, lung cancer, breast cancer, colon cancer, liver cancer, and head and neck cancer were analyzed for the levels of GALNS and PAEP by ELISA.

RESULTS:

The median serum levels of GALNS and PAEP in all cancer types as well as pneumonia patients were significantly higher than those of the healthy controls.

CONCLUSION:

In addition to previously known cancers, the median serum levels of PAEP were also found to be higher in liver and head and neck cancer patients. GALNS and PAEP are promising general biomarkers for multiple cancers and deserve further evaluation.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Condroitinsulfatasas / Glicodelina / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Anticancer Res Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Condroitinsulfatasas / Glicodelina / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Anticancer Res Año: 2019 Tipo del documento: Article