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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
Noordam, Raymond; Bos, Maxime M; Wang, Heming; Winkler, Thomas W; Bentley, Amy R; Kilpeläinen, Tuomas O; de Vries, Paul S; Sung, Yun Ju; Schwander, Karen; Cade, Brian E; Manning, Alisa; Aschard, Hugues; Brown, Michael R; Chen, Han; Franceschini, Nora; Musani, Solomon K; Richard, Melissa; Vojinovic, Dina; Aslibekyan, Stella; Bartz, Traci M; de Las Fuentes, Lisa; Feitosa, Mary; Horimoto, Andrea R; Ilkov, Marjan; Kho, Minjung; Kraja, Aldi; Li, Changwei; Lim, Elise; Liu, Yongmei; Mook-Kanamori, Dennis O; Rankinen, Tuomo; Tajuddin, Salman M; van der Spek, Ashley; Wang, Zhe; Marten, Jonathan; Laville, Vincent; Alver, Maris; Evangelou, Evangelos; Graff, Maria E; He, Meian; Kühnel, Brigitte; Lyytikäinen, Leo-Pekka; Marques-Vidal, Pedro; Nolte, Ilja M; Palmer, Nicholette D; Rauramaa, Rainer; Shu, Xiao-Ou; Snieder, Harold; Weiss, Stefan; Wen, Wanqing.
Afiliación
  • Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. r.noordam@lumc.nl.
  • Bos MM; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Wang H; Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
  • Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • de Vries PS; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Sung YJ; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Cade BE; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Manning A; Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Aschard H; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Brown MR; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Chen H; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
  • Franceschini N; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
  • Musani SK; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Richard M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Vojinovic D; Center for Precision Health, School of Public Health & School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Aslibekyan S; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Bartz TM; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  • de Las Fuentes L; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Feitosa M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Horimoto AR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Ilkov M; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
  • Kho M; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Kraja A; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Li C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Lim E; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
  • Liu Y; Icelandic Heart Association, Kopavogur, Iceland.
  • Mook-Kanamori DO; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Rankinen T; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Tajuddin SM; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA.
  • van der Spek A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Wang Z; Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Marten J; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
  • Laville V; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands.
  • Alver M; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Evangelou E; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  • Graff ME; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • He M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Kühnel B; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Lyytikäinen LP; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
  • Marques-Vidal P; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Nolte IM; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
  • Palmer ND; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Rauramaa R; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Shu XO; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Snieder H; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Weiss S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Wen W; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nat Commun ; 10(1): 5121, 2019 11 12.
Article en En | MEDLINE | ID: mdl-31719535
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Filogenia / Sueño / Polimorfismo de Nucleótido Simple / Sitios Genéticos / Lípidos Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Filogenia / Sueño / Polimorfismo de Nucleótido Simple / Sitios Genéticos / Lípidos Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article