Thyroid disrupting chemicals and developmental neurotoxicity - New tools and approaches to evaluate hormone action.
Mol Cell Endocrinol
; 518: 110663, 2020 12 01.
Article
en En
| MEDLINE
| ID: mdl-31760043
ABSTRACT
It is well documented that thyroid hormone (TH) action is critical for normal brain development and is mediated by both nuclear and extranuclear pathways. Given this dependence, the impact of environmental endocrine disrupting chemicals that interfere with thyroid signaling is a major concern with direct implications for children's health. However, identifying thyroid disrupting chemicals in vivo is primarily reliant on serum thyroxine (T4) measurements within greater developmental and reproductive toxicity assessments. These studies do not examine known TH-dependent phenotypes in parallel, which complicates chemical evaluation. Additionally, there exist no recommendations regarding what degree of serum T4 dysfunction is adverse, and little consideration is given to quantifying TH action within the developing brain. This review summarizes current testing strategies in rodent models and discusses new approaches for evaluating the developmental neurotoxicity of thyroid disrupting chemicals. This includes assays to identify adverse cellular effects of the brain by both immunohistochemistry and gene expression, which would compliment serum T4 measures. While additional experiments are needed to test the full utility of these approaches, incorporation of these cellular and molecular assays could enhance chemical evaluation in the regulatory arena.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
/
Hormonas Tiroideas
/
Disruptores Endocrinos
/
Trastornos del Neurodesarrollo
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
2020
Tipo del documento:
Article